Development of Diabetes Antioxidants that Target ROS Sources
Under pathological conditions, mitochondria are a major source of intracellular ROS, which play an important role in the pathogenesis of several diseases or pathological processes. excessive production and accumulation of ROS leads to oxidative stress in pancreatic β-cells and promotes the development of diabetes and related complications. One strategy for the treatment of diabetes and diabetic complications is to mitigate oxidative stress by reducing ROS production.
As a leader in the field of cellular stress, Creative Bioarray can help our customers develop drugs that target ROS-derived diabetes. We use the electrical potential gradient inside and outside the mitochondrial membrane to allow antioxidants to enter the mitochondria with the help of lipophilic cations (TPP), thus achieving targeted elimination of ROS sources.
How we guarantee the quality of our services
- We have a dedicated research team that can design drugs to target ROS-derived diabetes according to our clients' requirements
- We have a proven biological and chemical synthesis platform to handle antioxidant synthesis tasks
- We have extensive experience in providing complete targeted antioxidant evaluation solutions
- We have a proven animal testing platform to simulate multiple diseases for in vivo targeted antioxidant evaluation
Strategies for Development of Diabetes Antioxidants that Target ROS Sources
To develop drugs targeting ROS-derived diabetes, we attach antioxidants (e.g., vitamin E, panthenol, and n-acetylcysteine) to lipophilic cations. The lipophilic cations should deliver their attached antioxidants to the mitochondria, thereby preventing oxidative damage to the mitochondria.
Antioxidants attached to lipophilic cations accumulate rapidly through isolated mitochondria and intracellular mitochondria. Because of this selective accumulation, targeted antioxidants protect mitochondrial function from oxidative damage more effectively than they do on their own.
Synthesis and Evaluation of Drugs Targeting ROS Sources
Synthesis of target antioxidant-TPP drugs
We customize the appropriate synthesis according to the client's target antioxidants (vitamin E, panthenol and N-acetylcysteine, etc.). Antioxidants are accumulated through isolated mitochondria.
Detection of antioxidants-TPP' protective effect against oxidative damage caused by ROS sources
Incubate ROS sources with antioxidant-TPP to verify their role in preventing oxidative damage and reducing lipid peroxidation (thiobarbituric acid reactive substances) and protein damage (protein carbonyls).
- Determine whether the target antioxidant-TPP is taken up by mitochondria in human cells.
- Determine the cumulative efficiency of the targeted antioxidant in mitochondria.
Creative Bioarray is dedicated to providing high-quality products, comprehensive services, and tailored solutions to support and facilitate life sciences and pharmaceutical research and development. If you have any questions or needs, please contact us, and our customer service staff will help you the first time.
All services and products are for scientific use only, not for medical use！
