Efficacy Evaluation Service for Anti-aging Substances
UVA in sunlight is the main cause of skin light damage. It has strong penetration. About 20% ~ 30% of UVA can pass through the epidermis and reach the dermis, causing collagen reduction and abnormal elastic fiber deposition. Short time high-dose UVA irradiation can cause acute light damage such as painful erythema, blister, fever and nausea. At the same time, UVA can induce the production of reactive oxygen species, cause oxidative stress reaction, and cause fibroblast damage or apoptosis.
The relationship between free radicals and diseases has become a research hotspot in the field of modern medicine and life sciences. Antioxidants can reduce or eliminate free radicals, prevent or reduce the damage of free radical oxidative stress. At the same time, more and more natural or synthetic substances have been found to have antioxidant function, and it is very important to determine the effect and mechanism of their antioxidant components in the development of anti free radical drugs or antioxidants.
Creative Bioarray provides screening and evaluation services for skin fibroblast antioxidants and anti-aging drugs / components. As experts in the field of cell stress, we can provide customers with one-stop services. At the same time, our experimental scheme is very flexible. Customers can choose different schemes according to their own needs.
Service Process
Demand communication
When you choose our skin antioxidant and anti-aging drug / ingredient candidate drug screening and evaluation services, you first need to inform us of your needs.
Experimental purpose
- Select the drug with the best effect from multiple candidate drugs
- Evaluation of selected antioxidants
Determine modeling means
- Acute stress of fibroblasts induced by UVB
- Fibroblast stress stimulated by moderate and low levels of ultraviolet light
- Oxidative stress induced by 8-MOP/UVA
- If you have other modeling requirements, please inform us in advance
Develop and exchange experimental programs
- Modeling. We can select the source of oxidative stress according to the requirements of customers, and establish stress models based on selected fibroblast lines.
- Drug treatment. Provide anti ROS drug / antioxidant administration experiment, pharmaceutical pharmacology, efficacy evaluation and pharmacokinetic analysis according to customer requirements. We will conduct rigorous grouping experiments according to different experimental purposes.
Experiment execution
We have established a complete platform for cell culture and analysis, and developed a set of mature standards for cell oxidative stress water balance. We will analyze and compare the ROS content, cell viability, cell proliferation ability and the expression of apoptosis related genes of the tested cells before and after administration.
Data analysis and submission of experiment report
Creative Bioarray is dedicated to providing high-quality products, comprehensive services, and tailored solutions to support and facilitate life sciences and pharmaceutical research and development. If you have any questions or needs, please contact us, and our customer service staff will help you the first time.
All services and products are for scientific use only, not for medical use！
