Pig Oxidative Stress Modeling Service
Under oxidative stress, the polyunsaturated fatty acids constituting the cell membrane are oxidized, resulting in damage to the structure and functional integrity of the cell membrane, oxidative damage to proteins and nucleic acids, changes in enzyme activity, decline in the immune capacity of the body, and then induce various diseases. In animal production, oxidative stress often leads to a decline in food intake, growth rate, meat quality, reproductive ability to breed animals, and metabolic diseases, which brings great economic losses to animal husbandry.
Therefore, exploring the mechanism and defense strategy of oxidative stress in animal production has always been a hot spot in animal nutrition research. Constructing a reliable animal model and evaluation method of oxidative stress is of great significance for revealing the mechanism of oxidative stress and developing antioxidant stress additives.
Creative Bioarray provides our customers with oxidative stress modeling solutions and modeling services for piglets and growing pigs. We will recommend injectable or foodborne induction methods for customers as needed.
Available Modeling Methods at Creative Bioarray
- Food bore piglet modeling service using foods containing lipid peroxidation products as stressors
Some animal oils, such as fish oil, are rich in polyunsaturated fatty acids (PUFA). During storage, a large number of lipid peroxidation products will be formed due to the effects of oxygen, light, humidity, temperature, and constant and trace elements. These products will not only affect the feed lipid utilization but also cause oxidative stress to livestock and poultry.
- Intraperitoneal injection piglet model with toxic compounds as stressors
Some herbicides can use molecular oxygen to produce O2- and H2O2 to induce oxidative stress in animals.
- Intraperitoneal injection growth pig model with toxic compounds as stressors
How We Guarantee the Modeling Quality
In addition to the direct use of hydrogen peroxide as the stressor, we also use arterial intubation, intravenous intubation, gavage, and intraperitoneal injection as required in addition to intramuscular injection, drinking water, or food intake.
Considering that in some cases, only one injection may not be enough, we will further explore the injection of similar stressors every other week or even every day, to better simulate the actual production process similar to the situation of long-term oxidative stress.
In addition to indirect indicators such as SOD, cat, and MDA, we also use a free radical analyzer to analyze the new increase of free radicals during or shortly after stress to quantitatively evaluate the state of oxidative stress.
We will also analyze the DNA damage of relevant tissues and organs, to more accurately reflect the number of new free radicals produced by the animal body after stress, and how much damage these free radicals have caused to the body.
Creative Bioarray is dedicated to providing high-quality products, comprehensive services, and tailored solutions to support and facilitate life sciences and pharmaceutical research and development. If you have any questions or needs, please contact us, and our customer service staff will help you the first time.
All services and products are for scientific use only, not for medical use！
