Solutions for Oxidation Related Genes
Oxidative damage to DNA is a constant threat to genomic integrity, and reactive oxygen species, a byproduct of normal aerobic metabolism, can lead to this threat when DNA is attacked by reactive oxygen species (ROS). In addition, oxidative stress leads to the activation or repression of many genes in important signaling pathways. Also one mechanism by which humans protect themselves from oxidative stress is through an endogenous stress response that leads to transcriptional activation of antioxidant response elements (ARE).
As a leader in the field of cellular oxidative stress, Creative Bioarray offers a range of molecular biology solutions related to cellular oxidative stress to our research partners. We can help our customers to
- Identify candidate DNA products with antioxidant potential
- Screen and identify transcriptional activators of antioxidant genes in target cells
- Assess oxidative stress-induced gene expression by high-throughput methods
Creative Bioarray provides our customers with solutions to identify and characterize gene products that prevent or repair oxidative DNA damage. In addition, we perform subcellular localization of the identified gene products. This solution is expected to provide the scientific basis for research and treatment of oxidative stress-related diseases in humans.
Creative Bioarray can identify ARE activators on a genomic scale by screening expression cDNA libraries in high-throughput reporter gene analysis and testing the ability of cDNAs to upregulate endogenous AREs at the transcriptional and protein levels to regulate gene expression and their ability to protect cells from oxidative damage.
Creative Bioarray offers a solution to study transcriptional changes in redox-engineered cell lines using gene expression microarrays. This solution can be used to assess gene expression changes induced by oxidative stress in mammalian cells and tissue samples in high throughput and is highly applicable to other biological systems that can be used to assess oxidative stress.
Creative Bioarray is dedicated to providing high-quality products, comprehensive services, and tailored solutions to support and facilitate life sciences and pharmaceutical research and development. If you have any questions or needs, please contact us, and our customer service staff will help you the first time.
All services and products are for scientific use only, not for medical use！
