Myocardial Oxidative Stress
The heart is the most important organ in the circulatory system and the main pump of the whole circulatory system of life. The myocardium is a kind of muscle tissue composed of myocardial cells. Myocardial cells are not only distributed on the heart wall but also in the adjacent large blood vessels.
Under many pathological conditions, excessive production of oxygen free radicals has been found in myocardial tissue, making myocardial cells in a state of excessive accumulation of reactive oxygen species or related substances, that is, oxidative stress, which further produces a variety of toxic effects on cells, leading to reversible or irreversible damage. Oxidative stress can not only cause necrosis of cardiomyocytes but also cause apoptosis of cardiomyocytes.
The myocardial oxidative stress model has been widely used in related drug production mechanisms and new drug discoveries. Due to the different formation mechanisms of various cardiomyocyte models, the reasonable selection of cardiomyocyte stress models is of great significance for the study of the mechanism of drug action.
Creative Bioarray provides our customers with a variety of services related to oxidative stress in cardiomyocytes.
The establishment of the cardiomyocyte oxidative stress model is helpful to observe the effects of antioxidants or other substances on various oxidative stress indexes and apoptosis of cardiomyocytes, to reveal the protective effect of antioxidants on cardiomyocytes, or the toxicity of external substances on cardiomyocytes. The stressor we used includes but is not limited to Sodium Arsenite, High Glucose H2O2, and Hypoxia / Reoxygenation.
We provide antioxidant rescue assessment services. Based on the established myocardial oxidative stress model, we can provide anti-free radical drug / antioxidant administration experiments, pharmacy pharmacology, efficacy evaluation, and pharmacokinetic analysis at the same time.
Some drugs have the potential for myocardial cell toxicity, which may seriously cause the risk of cardiovascular diseases such as heart failure, myocardial hypertrophy, and congestive heart failure.
We provide our clients with drug myocardial cytotoxicity assessment services.
To explore the relationship between target genes and oxidative stress, Creative Bioarray has developed a one-stop experimental platform. First, according to the requirements of customers, simulate the environment of cellular oxidative stress, and then study the expression changes of target genes based on the cell model. This service is expected to help customers explore the interaction between cell oxidative stress and specific genes.
Creative Bioarray is dedicated to providing high-quality products, comprehensive services, and tailored solutions to support and facilitate life sciences and pharmaceutical research and development. If you have any questions or needs, please contact us, and our customer service staff will help you the first time.
All services and products are for scientific use only, not for medical use！
