Non-oxidative Cellular Stress Assay
Stress on cells and organisms comes from a variety of sources, including mechanical damage, pathogens, toxic compounds in the environment, natural substances that damage cells, such as ultraviolet light, nutrient or oxygen deprivation, and more. These cellular stressors damage macromolecules, cells, and organisms in a variety of ways, from altering the normal function of cells and tissues to disrupting the growth and reproduction of organisms. To help our clients study cellular and organismal stress and responses to stress in the context of environmental pollution, DNA damage, viral infection, metal contamination, hypoxia, high temperature, etc.
Creative Bioarray offers non-oxidative cellular stress assay services.In addition to oxidative stress, we can detect up to 11non-oxidative stress critical cellular stress mechanisms(gene regulation, ER stress, DNA damage, inflammation, hypoxia, mitochondrial stress, heat shock, osmotic stress, metal stress, lipid accumulation, general cell health.)
Molecular Markers Detectable in Cellular Stress Panel Assays
| Cellular Stress Mechanism |
Detectable Molecular Markers |
| Gene regulation |
AhR translocation |
| ER stress |
BiP, XBP1, ATF4, EPRK, CHOP, ER integrity |
| DNA damage |
p-H2AX, Phospho-p53 |
| Inflammation |
ICAM1, IL-8, NFkB, TNFAIP3, IL1-β, IL-6, INF-γ |
| Hypoxia |
HIF1α |
| Mitochondrial stress |
Mitochondrial ROS, PGC1α, Mitochondrial mass, Mitochondrial membrane potential, OCR, Reserve capacity |
| Oxidative stress |
NRF2, SRXN1, HMOX1, Glutathione content, ROS |
| Heat shock |
HSP 70 |
| Osmotic stress |
NFAT |
| Metal stress |
Metallothionein, MTF1 |
| Lipid accumulation |
Phospholipidosis, Steatosis |
| General cell health |
LDH release, ATP content, cell count, nuclear size, membrane permeability, intracellular pH, Caspase 3/7, cell cycle arrest |
Related Services
Creative Bioarray provides services to detect and analyze the effects of hypoxic stress on the survival, proliferation, apoptosis, and gene expression of different cell types. We help our customers to investigate the signaling regulation of stress response and its molecular mechanisms.
Creative Bioarray provides our clients with services to detect the molecular mechanisms of miRNAs in heat stress. We can help our clients to screen the target genes of miRNAs during heat stress and thus determine the mechanism of action and the significance of miRNAs against heat stress.
Creative Bioarray is dedicated to providing high-quality products, comprehensive services, and tailored solutions to support and facilitate life sciences and pharmaceutical research and development. If you have any questions or needs, please contact us, and our customer service staff will help you the first time.
All services and products are for scientific use only, not for medical use！
