Development of Antioxidative for Diabetes Treatment
Diabetes is a chronic disease characterized by hyperglycemia due to decreased insulin secretion or insulin resistance, which prevents the body from responding adequately to insulin. A growing body of research suggests that oxidative stress plays a key role in the pathogenesis and progression of diabetes.
Because of the close and complex association between oxidative stress and diabetes, the development of antioxidants for the treatment of diabetes is imminent. However, the efficiency of antioxidants is low, probably due to poor solubility, poor permeability, unstable storage, first-pass metabolism or gastrointestinal degradation of conventional antioxidants (e.g. enzyme antioxidant mimetics, vitamin C and vitamin E). Therefore, there is a need to develop novel delivery methods for antioxidants and specific drugs targeting oxidative stress and redox modifications.
As an expert in the field of cellular stress, Creative Bioarray provides our customers with solutions for antioxidants for the treatment of diabetes. Our main strategy is to improve the solubility, permeability and stability of antioxidants through novel antioxidant delivery systems (NDDS) or to develop antioxidant drugs targeting ROS sources.
Novel Antioxidant Delivery Systems
Some dietary antioxidants, such as catalase, vitamin C, have poor solubility, permeability, and stability in conventional delivery systems, which can lead to disappointing results in clinical trials. Many NDDS can improve the solubility, permeability and stability of antioxidants, including particulates, nanoparticles and liposomes.
| Diseases |
Oxidative Stress-Related MicroRNAs |
| Microparticle |
Promotes the entry of antioxidants with poor membrane permeability |
| Nanoparticle |
Increases the bioavailability of antioxidants |
| Liposome |
Improves antioxidative capacity of antioxidants |
Reducing ROS production is a fundamental strategy to alleviate oxidative stress. A large number of clinical trials targeting ROS sources targeting diabetes and diabetic complications are currently ongoing. We use the electrical potential gradient inside and outside the mitochondrial membrane to allow antioxidants to enter the mitochondria with the help of lipophilic cations (TPP), thus achieving targeted elimination of ROS sources.
Creative Bioarray is dedicated to providing high-quality products, comprehensive services, and tailored solutions to support and facilitate life sciences and pharmaceutical research and development. If you have any questions or needs, please contact us, and our customer service staff will help you the first time.
All services and products are for scientific use only, not for medical use！
