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Oxidative Stress in Drug Development

Oxidative Stress in Drug Development

Among the many factors that contribute to cancer or other diseases such as diabetes, oxidative stress is one of the most important and well-studied events that elevate the conditions that lead to tumor onset and progression. Oxidative stress and chronic inflammatory processes are tightly coupled and failure to stop these processes may lead to genetic/epigenetic changes that can trigger cancer. In addition excessive damage caused by ROS may be associated with changes in mitochondrial membrane permeability, leading to cytochrome C release and apoptosis.

Antioxidants, as chemicals that interact with neutralizing free radicals, can prevent them from causing damage. Targeting these biochemical properties of cancer cells with redox-regulated strategies is a viable therapeutic approach to achieve therapeutic selectivity and overcome drug resistance. As a leader in the field of cellular stress, Creative Bioarray provides clients with antioxidant development services targeting mitochondria for the treatment of diabetes and disease.

A Targeting Strategy - Development of Antioxidants Targeting Mitochondria

Mitochondria are a major source of intracellular ROS, therefore, delivery of antioxidant therapies to mitochondria would be ideal. However, many of the most extensively studied compounds fail to localize within the mitochondria.

Creative Bioarray provides mitochondria targeting antioxidants (lipophilic cations-based, amino acids & peptides-based, and nitroxide radicals-based antioxidants) development and evaluation solutions for customers.

A Treatment - Development of Antioxidative for Diabetes Treatment

We provide our customers with solutions for antioxidants for the treatment of diabetes. Our main strategy is to improve the solubility, permeability and stability of antioxidants through novel antioxidant delivery systems (NDDS) or to develop antioxidant drugs targeting ROS sources.

  • Development of microparticle-based diabetic antioxidants      
  • Development and preclinical evaluation of nanoparticle-based diabetic antioxidants
  • Development and preclinical evaluation of liposome-based diabetic antioxidants
  • Development of diabetic antioxidants targeting ROS sources

Creative Bioarray is dedicated to providing high-quality products, comprehensive services, and tailored solutions to support and facilitate life sciences and pharmaceutical research and development. If you have any questions or needs, please contact us, and our customer service staff will help you the first time.

All services and products are for scientific use only, not for medical use!

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About Us

Creative Bioarray is a leading customer-focused biotechnology company. We are dedicated to providing high-quality products, comprehensive services, and tailored solutions to support and facilitate life sciences and pharmaceutical research and development.

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  • SUITE 115, 17 Ramsey Road, Shirley, NY 11967, USA
  • 1-631-626-9181
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