Development of Antioxidants Targeting Mitochondria

Mitochondria play an important role in controlling the life and death of cells. Therefore, mitochondrial dysfunction leads to a range of human diseases such as ischemia-reperfusion injury, sepsis, and diabetes mellitus. Mitochondria are a major source of intracellular ROS, and since mitochondria are most susceptible to oxidative damage, delivery of antioxidant therapies to mitochondria would be ideal.

Many of the most extensively studied compounds fail to localize within the mitochondria, or even enter the intracellular environment. As a leader in the field of cellular stress, Creative Bioarray can help our customers develop a range of antioxidants that target the mitochondria.

Antioxidants and Delivery Strategies

Types of antioxidants include, for example, antioxidant vitamins (e.g., ascorbic acid, alpha-tocopherol, beta-carotene), inorganic antioxidants (e.g., selenium), synthetic antioxidants (e.g., butylhydroxyanisole [BHA], butylhydroxytoluene [BHT], propyl gallate, 2,4,6-trimethylphenol), and a range of polyphenols of plant origin.

Fig. 1 An overview of mitochondrial functions and their dysfunction, along with some target inhibitors. (Buchke et al., 2022)

There are a range of possibilities for selective delivery of drugs to mitochondria, including targeting based on biophysical properties of mitochondria (e.g., high negative internal potential), targeting based on unique mitochondrial localization of enzymes catalyzing drug release from prodrugs, and targeting based on transporter-dependent delivery of prodrugs.

Creative Bioarray' Development Program for Mitochondria - Targeting Antioxidants

Lipophilic Cations-based Antioxidant Development Scheme

The potential gradient of the inner mitochondrial membrane is exploited to make the matrix side of the membrane negatively charged. Due to the electrolysis of the inner membrane, lipophilic cations tend to accumulate in the mitochondrial matrix.

Amino Acids & Peptides-based Antioxidant Development Scheme

A class of permeable peptide antioxidants targeting mitochondria, which can freely penetrate cells and they are highly concentrated in mitochondria.

Nitroxide Radicals-based Antioxidant Development Scheme

Development of a series of electron and ROS scavengers targeting mitochondria using stable nitroxide radicals.

How We Guarantee the Quality of Our Services

We have a professional research team that can design mitochondria-targeted antioxidant delivery systems according to customer requirements
We have a proven biological and chemical synthesis platform to handle antioxidant synthesis tasks
We have rich experience in providing complete targeted antioxidant evaluation solutions
We have a proven animal testing platform to simulate multiple diseases for in vivo targeted antioxidant evaluation

Creative Bioarray is dedicated to providing high-quality products, comprehensive services, and tailored solutions to support and facilitate life sciences and pharmaceutical research and development. If you have any questions or needs, please contact us, and our customer service staff will help you the first time.

Reference

Buchke, S., Sharma, M., Bora, A., Relekar, M., Bhanu, P., & Kumar, J. (2022). Mitochondria-Targeted, Nanoparticle-Based Drug-Delivery Systems: Therapeutics for Mitochondrial Disorders. Life, 12(5), 657.

All services and products are for scientific use only, not for medical use！