At present, the methods of studying immune stress and oxidative stress mainly include an animal model method and the cell model method. Although the establishment of a cell model is rapid, only a single cell model in Vitro cannot reflect the complex physiological processes and mechanisms in Vivo.
Stress refers to a series of nonspecific reactions when animals are stimulated by endogenous or exogenous stressors. When animals are stimulated by stressors, they will be excited by sympathetic nerves, and the secretion of pituitary and adrenocortical hormones will increase, resulting in decreased feed intake, decreased feed conversion rate, and enhanced catabolism, and decreased immune function. Stress has caused serious harm to animal health and production performance and has become the main factor restraining the development of large-scale intensive breeding.
The common stresses in modern animal breeding mainly include nutritional stress, environmental stress, oxidative stress, and immune stress, of which the latter two are the focus of current research. At present, Creative Bioarray has established stress models in mice, chickens, pigs, and other animals, and through anti oxidase, malondialdehyde (MDA), reactive oxygen species (ROS), interleukin-1 (IL-1), interleukin-6 (IL-6), tumor necrosis factor α and other immune indexes to determine whether the stress model is successfully established.
The successful establishment of a stress model is the prerequisite for the smooth progress of anti-stress research. Therefore, the establishment of an appropriate animal stress model has become the primary issue in the study of oxidative stress, immune stress mechanism, and the development of anti-stress drugs.
We provide our customers with oxidative stress modeling solutions and modeling services for piglets and growing pigs. We will recommend injectable or foodborne induction methods for customers as needed.
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