Digestive System Stress Model
Oxidative stress refers to the increase of free radicals or the weakening of antioxidant protection ability under the stimulation of harmful factors in vivo and in vitro, resulting in the imbalance of oxidative system and antioxidant system. In this state, excessive accumulation of reactive oxygen species (ROS) will cause damage to biological molecules such as nucleic acids, proteins and lipids.
Digestive system is one of the eight systems of human body. It is composed of digestive tract and digestive gland. With the development of new cell technology, the research on oxidative stress of intestinal cells and liver cells is gradually increasing.
Our Services
Cell model method is to treat cells with stress sources, destroy the normal redox state in cells, produce substances that can damage DNA, RNA, protein, lipid and other intracellular components, play a toxic role, and simulate the oxidative stress state in the body. Therefore, it can effectively reflect the absorption, metabolism and utilization of harmful substances and antioxidants in cells, and accurately simulate the internal environment of organisms, The best cell line can also be selected according to the research purpose to establish a model, which can not only study the oxidative damage effect and mechanism of harmful substances on cells in vivo and in vitro, but also effectively evaluate or screen antioxidants.
As a leader in the biotechnology industry, Creative Bioarray provides our customers with the establishment of oxidative stress models of intestinal epithelial cells, ordinary hepatocytes, liver, stellate cells and liver cancer cell lines. We can conduct induction modeling in a variety of ways to make it suitable for various research purposes.
What We Can Do
Intestinal Epithelial Oxidative Stress Cell Model Construction Service
We exposed the primary and subcultured intestinal epithelial cells to physical or chemical stressors, and then completed the stress model establishment of the intestinal epithelial cells.Primary cultured cells can truly reflect the characteristics of intestinal epithelial cells, but they have the disadvantages of cumbersome operation and long-term use. There are many kinds of cells subcultured, so researchers need to choose the species and genera studied.
Hepatic Stellate Cell Oxidative Stress Model
We have constructed the oxidative stress model of primary rat hepatic stellate cells (rHSC) and activated human hepatic stellate cell line (LX-2). These two models can basically represent the main oxidative stress molecules in the liver.
Hepatoma Cell Oxidative Stress Model
We have established a cell oxidative stress model mediated by hydrogen peroxide H2O2) for customers to provide a cytological model for screening antioxidant active substances and revealing the mechanism of antioxidant stress.
Hepatocyte Oxidative Stress Model
We are able to induce human, mouse and chicken liver cells in many ways to make them suitable for a variety of research purposes.
Creative Bioarray is dedicated to providing high-quality products, comprehensive services, and tailored solutions to support and facilitate life sciences and pharmaceutical research and development. If you have any questions or needs, please contact us, and our customer service staff will help you at the first time.
All services and products are for scientific use only, not for medical use！
