Nervous System Oxidative Stress Modeling Service
The biochemical integrity of the brain is essential for the normal function of the central nervous system (CNS). One of the factors leading to brain biochemical damage is a chemical process called oxidative stress. Oxidative stress occurs when too many free radicals are produced due to the lack of antioxidant response system. The brain has high oxygen consumption and high lipid content, and is vulnerable to oxidative stress. Therefore, the brain damage caused by oxidative stress is likely to have a negative impact on the normal function of the central nervous system.
Creative Bioarray provides our customers with in vitro oxidative stress modeling services for Nervous System. Based on these established models, we can simultaneously provide anti-free radical drug / antioxidant administration experiments, pharmacy pharmacology, efficacy evaluation, and pharmacokinetic analysis. The purpose of this service is to promote the screening and development of antioxidants and anti-free radicals in the nervous system.
Available Stressed Nervous Model at Creative Bioarray
Rat adrenal pheochromocytoma line (PC12) is a good model to study the physiology, pathology and pharmacology of nerve cells. The full name of N2a cells is mouse neuroblastoma N2a cells, or Neuro-2a. It is a mouse neuroblastoma mother cell. At present, the cell line is mainly cultured in the laboratory as a cell model for in vitro pathological research, and it is also a common cell model for Alzheimer's disease research.
SK-N-SH is a human neuroblastoma cell line, which was established by J.L.Bieder. SK-N-SH was used as a target cell line in cell-mediated cytotoxicity test.
SH-SY5Y cell is a subline of neuroblastoma SK-N-SH cell line after three clones. SH-SY5Y cells show moderate levels of dopamine- β - hydroxylase activity.
U373 is a human glioblastoma cell line. We used Fenton reagent or human neuromelanin to induce oxidative damage in this cell line.
The glioma cell line C6 was cloned from rat glioma induced by N-nitrosourea by Benda et al., and was established after a series of in vitro culture and animal passage.
Related Solutions
Creative Bioarray can use neuron cell / neuroblastoma cell line / glioblastoma cell line as an oxidative stress model to help our customers study the changes of signal transduction pathways, transcription factors, gas signal molecules, etc.
Creative Bioarray can now provide screening and evaluation services for candidates of antioxidants and anti-free radical drugs based on the oxidative stress model of neuron cell / neuroblastoma cell line / glioblastoma cell line.
Creative Bioarray has developed a one-stop platform for regulating oxidative stress in nerve cells. We can regulate and improve the state of oxidative stress in cells through micro RNA.
Creative Bioarray is dedicated to providing high-quality products, comprehensive services, and tailored solutions to support and facilitate life sciences and pharmaceutical research and development. If you have any questions or needs, please contact us, and our customer service staff will help you the first time.
All services and products are for scientific use only, not for medical use！
